ABSTRACT
Objective: To compare prevalence of overweight/obesity among adolescent school children of government and private schools. Methods: A school-based cross-sectional study was conducted in 1800 children aged 10-16 years. Body mass index (BMI), Waist circumference (WC), Hip circumference (HC), and Neck circumference (NC) were measured using standard guidelines. Results: The prevalence of overweight / obesity was 27.8% (private schools - 45.2%, government schools – 10.5%). BMI, WC, NC, and Waist-hip ratio were significantly higher among private school students. Conclusion: A differential strategic plan may be needed to prevent and control obesity among adolescent school children.
ABSTRACT
Background: Hypertensive disorders of human pregnancy, such as preeclampsia, complicates a sizeable percentage of all pregnancies, need its early indication and warning. The aim of present study was to determine the association between lipid peroxidation product, serum malondialdehyde (MDA) and serum uric acid levels in preeclampsia and find out any association between these two parameters in preeclampsia. Methods: Thirty preeclampsia and thirty gestational age matched normotensive pregnant women attending Narayana General Hospital, Nellore were included in the study. Serum MDA levels were measured by Thiobarbituric acid reactive substances(TBARS) method and serum uric acid levels were estimated by automated chemistry analyser using commercial kits. Results: Serum MDA (Mean±SEM 24.4±2.38 vs 7.9± 0.28 nmol/ml, p value < 0.000) and serum uric acid levels (7.2 ± 0.25 vs 3.9 ± 0.14 mg/dl, p value <0.000) were significantly elevated in preeclampsia cases when compared with that of normotensive pregnant women. A weak positive correlation between serum uric acid and serum MDA (r value 0.065, p value 0.734) was noticed in preeclampsia. Conclusion: Serum MDA and uric acid may be included as additional markers for screening and progression of preeclampsia, thereby helpful in effectively treating the condition at an early stage.
ABSTRACT
Pregnancy is a stressful condition in which many physiological and metabolic functions are altered to considerable extent and hypertension is the most commonest problem encountered during pregnancy, complicating 5-10% of pregnancies. Recent reports suggest that free radical induced endothelial damage as an important factor in the pathogenesis of preeclampsia. Such cell injury might in turn is counteracted by the action of several in vivo antioxidants. But because of increased lipid peroxidation and increased demand of antioxidants , increased oxidative stress is suspected. The present study was undertaken to determine serum malondialdehyde (MDA) and RBC reduced glutathione (GSH) levels in clinically diagnosed preeclamptic women (n=30) and compared with that of normotensive pregnant women and to find out any association between the two parameters. Serum MDA levels were significantly elevated (p value<0.000) and RBC reduced GSH levels were significantly decreased ( p value <0.000) compared to that of normotensive pregnant women. A statistically significant negative correlation was observed between serum MDA and RBC reduced GSH (p value <0.003) in preeclamptic cases.
ABSTRACT
Hypertensive disorders during pregnancy increase maternal and fetal risk. Preeclampsia is characterised by hypertension and proteinuria. Increased uric acid is a key clinical feature of preeclampsia; higher levels correlate with significant maternal and fetal morbidity and mortality. The present study was undertaken to estimate serum uric acid , the end product of purine catabolism, in clinically diagnosed preeclamptic women (n=30) and the values were compared with that of normotensive pregnant women (n=30) ,aged 18-30yrs. All of them were in their third trimester and primigravida. Serum uric acid levels were measured by spectrophotometry. We observed that serum uric acid levels were increased significantly when compared with that of normotensive pregnant women (p value < 0.000).
ABSTRACT
Organophosphorous (OP) poisoning is an ever increasing and troublesome situation in the developing countries and is a major health care challenge in the 21st century. Hundred patients who attempted suicide with organophosphates, admitted to the emergency services were included in the study. They were graded (grade 0,1,2,3) according to clinical findings and examined for parameters like RBS, serum urea, serum creatinine, liver function tests, serum amylase, serum cholinesterase and LDH . The APACHE (II) of the cases were determined and correlated with severity of the clinical manifestations. A significant decline in serum cholinesterase (ChE) with increasing grades of intoxication(p <0.05) was observed along with raised levels of random blood sugar, serum urea, creatinine, hepatic enzymes and amylase. APACHE(II) score, showed a significant rise with severity of the degree of intoxication (p<0.001) and a negative correlation with serum cholinesterase. The findings of this study highlighted usefulness of biochemical and clinical indices in the management of organophosphorous poisoning thereby recognizing the complications early and facilitating early management.